Figure 8. Responsiveness to aldosterone is increased in colon of mice with Liddle's syndrome mutation.

ΔI_SC-Ami and P_Aldo values were taken from the experiments summarized in Fig. 2. For each genotype (WT, top panel; +/L, middle panel; L/L, lower panel), the average ΔI_SC-Ami values are plotted against the corresponding average P_Aldo values from animals maintained on a standard (○), high (•) or low (▾) salt diet (vertical and horizontal bars indicate s.e.m. values). Linear regression of the mean values revealed a significantly (P < 0.01) steeper slope in L/L and +/L animals compared with the wild-type animals. The predicted intercepts of the regression lines with the y-axis are indicated by stars and suggest that baseline ENaC activity at a hypothetical P_Aldo of zero is higher in L/L and +/L animals than in wild-type animals.