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. 2007 Nov 8;586(Pt 2):427–439. doi: 10.1113/jphysiol.2007.145151

Figure 2. IIRK and IDRK.

Figure 2

A and B, percentage of microglial cells in culture showing just IIRK (^, ± s.e.m.), just IDRK (▵, ± s.e.m.) or IIRK+DRK (•, ± s.e.m.) depending on time in subculture (A, day 1 n = 4, 2 n = 3, 3 n = 4, 4 n = 4, 5 n = 2, 6 n = 3, 7 n = 3 coverslips, 183 cells) and incubation time in 1 μg ml−1 LPS (B, 0 h n = 16, 3 h n = 4, 6 h n = 4, 12 h n = 2, 24 h n = 4, 48 h n = 3 coverslips, 247 cells). C, D and E, typical current–voltage relationships (I–V) of whole-cell currents in microglial cells revealing just IIRK (C), just IDRK (D) and both, IIRK+DRK (E). F and G, average inward (IRK, •, ± s.e.m.) and outward (DRK, ^, ± s.e.m.) currents (in pA pF−1) measured at −110 and +80 mV, respectively, of microglial cells depending on time in subculture (F, day 1 n = 36, 2 n = 22, 3 n = 37, 4 n = 32, 5 n = 17, 6 n = 19, day 7 n = 18 cells) and (G) incubation time in 1 μg ml−1 LPS (circles, 0 h n = 123, 3 h n = 18, 6 h n = 27, 12 h n = 15, 24 h n = 28, 48 h n = 25 cells). The controls (0 h LPS) in B and G represent the average data from day 3 to day 7 in A and F, respectively.