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. 2007 Nov 22;586(Pt 3):899–911. doi: 10.1113/jphysiol.2007.143586

Figure 3. Intermittent hypoxia reversed the normal diurnal glucose rhythm and caused a relative hypoglycaemia during the dark period.

Figure 3

A, changes in blood glucose over time during saline infusion (intermittent hypoxia, n = 17; intermittent air n = 13). B, changes in blood glucose over time during glucose infusion (intermittent hypoxia, n = 14; intermittent air n = 14; statistical difference determined by one-way ANOVA). C, averaged changes in blood glucose during the light and dark periods for all four experimental groups (note: data for dark period is plotted twice to highlight the diurnal rhythm). Significant differences between the light and dark periods within an experimental group are marked to the right of the figure. Analysis by two-way ANOVA revealed a significant effect of exposure (intermittent hypoxia < intermittent air; P < 0.0001) and infusion (glucose > saline; P < 0.0001), and a significant interaction (glucose infusion accentuated hypoglycaemia during intermittent hypoxia; P < 0.025).