Figure 5. Effect of intra-arterial injection of anandamide.

Anandamide was administered in normal animals alone or in the presence of: capsazepine (CPZ; a selective TRPv1 receptor antagonist, 100 (μg 100 μl)⁻¹); AM281 (a selective CB₁ antagonist, 100 mg (100 μl)⁻¹); or AM630 (a selective CB₂ antagonist, 10 μm). *Significantly different from AEA alone group; †significantly different from saline and vehicle trials within the AEA alone, CPZ and AM630 groups; ††significantly different from saline and vehicle trials within the AM281 group (P < 0.05).