. 2007 Nov 29;586(Pt 4):1195–1205. doi: 10.1113/jphysiol.2007.144113

Table 2.

Arterial and venous blood gas responses at rest and with incremental exercise during normoxia and hypoxia under each drug condition

	Normoxia			Hypoxia

	Rest	10%	20%	Rest	10%	20%
Control (no drug)
[Hb]_a (g dl⁻¹)	13.9 ± 0.4	14.2 ± 0.3	14.2 ± 0.4	14.1 ± 0.4	14.1 ± 0.4	14.3 ± 0.5
S_aO₂ (%)	97 ± 0	97 ± 0	97 ± 0	80 ± 1^*	82 ± 1^*	81 ± 1^*
P_aO₂ (Torr)	101 +3	107 ± 7	105 ± 3	45 ± 1^*	48 ± 1^*	49 ± 2^*
P_aO₂ (Torr)	38 ± 3	25 ± 1^†	25 ± 1^†	27 ± 2^*	24 ± 2^*	23 ± 1^*^†
Arterial O₂ content (ml l⁻¹)	190 ± 5	194 ± 5	195 ± 5	158 ± 4^*	163 ± 5^*	164 ± 4^*
Venous O₂ content (ml l⁻¹)	125 ± 11	77 ± 7^†	73 ± 4^†	86 ± 9^*	63 ± 7^*^†	64 ± 5^*^†
a–v O₂ (ml l⁻¹)	65 ± 10	117 ± 6^†	121 ± 5^†	72 ± 9	99 ± 8^*^†	102 ± 5^*^†
P_aCO₂ (Torr)	40 ± 1	40 ± 1	41 ± 1	38 ± 1	39 ± 1	40 ± 1
P_vCO₂ (Torr)	48 ± 1	55 ± 1^†	61 ± 1^‡	48 ± 2	53 ± 1^*^†	58 ± 2^*^‡
pH_a	7.4 ± 0.0	7.4 ± 0.0	7.4 ± 0.0	7.4 ± 0.0	7.4 ± 0.0	7.4 ± 0.0
pH_v	7.4 ± 0.0	7.3 ± 0.0	7.3 ± 0.0	7.4 ± 0.0	7.3 ± 0.0	7.3 ± 0.0
Phentolamine
[Hb]_a (g dl⁻¹)	14.2 ± 0.5	14.2 ± 0.5	14.3 ± 0.5	14.2 ± 0.3	14.2 ± 0.3	14.4 ± 0.3
S_aO₂ (%)	97 ± 0	97 ± 0	97 ± 0	81 ± 1^*	82 ± 0^*	83 ± 1^*
P_aO₂ (Torr)	102 ± 3	104 ± 3	103 ± 2	45 ± 1^*	47 ± 0^*	49 ± 1^*
P_vO₂ (Torr)§	54 ± 2	36 ± 1^†	32 ± 1^‡	40 ± 1^*	30 ± 1^*^†	28 ± 1^*^†
Arterial O₂ content (ml l⁻¹)	194 ± 6	194 ± 6	196 ± 6	161 ± 4^*	163 ± 4^*	167 ± 4^*
Venous O₂ content (ml l⁻¹)§	173 ± 6	127 ± 5^†	100 ± 6^†	140 ± 8^*	102 ± 7^*^†	87 ± 6^*^†
a-v O₂ (ml l⁻¹)§	21 ± 2	67 ± 5^†	96 ± 7^†	13 ± 2^*	61 ± 7^*^†	80 ± 7^*^†
P_aCO₂ (Torr)	40 ± 1	41 ± 1	40 ± 0	39 ± 1	39 ± 0	40 ± 1
P_vCO₂ (Torr)§	43 ± 1	49 ± 1^†	53 ± 1^‡	42 ± 1	46 ± 1^*^†	50 ± 1^*^‡
pH_a	7.4 ± 0.0	7.4 ± 0.0	7.4 ± 0.0	7.4 ± 0.0	7.4 ± 0.0	7.4 ± 0.0
pH_v§	7.4 ± 0.0	7.4 ± 0.0	7.3 ± 0.0	7.4 ± 0.0	7.4 ± 0.0	7.4 ± 0.0
Phentolamine/propranolol
[Hb]_a (g dl⁻¹)	13.8 ± 0.5	14.0 ± 0.4	14.1 ± 0.4	14.2 ± 0.4	14.2 ± 0.4	14.3 ± 0.3
S_aO₂ (%)	97 ± 0	97 ± 0	97 ± 0	82 ± 1^*	81 ± 1^*	82 ± 1^*
P_aO₂ (Torr)	97 ± 3	102 ± 2	100 ± 2	47 ± 1^*	47 ± 1^*	49 ± 1^*
P_vO₂ (Torr)§	55 ± 3	35 ± 3^†	31 ± 2^†	38 ± 1^*	28 ± 2^*^†	27 ± 2^*^†
Arterial O₂ content (ml l⁻¹)	186 ± 7	190 ± 6	192 ± 6	162 ± 5^*	160 ± 4^*	166 ± 4^*
Venous O₂ content (ml l⁻¹)§	167 ± 8	107 ± 8^†	101 ± 7^†	138 ± 6^*	94 ± 9^*^†	90 ± 8^*^†
a–v O₂ (ml l⁻¹)§	21 ± 3	83 ± 7^†	91 ± 7^†	24 ± 3	66 ± 8^*^†	76 ± 8^*^†
P_aCO₂ (Torr)	39 ± 1	40 ± 0	40 ± 1	39 ± 0	39 ± 0	40 ± 0
P_vCO₂ (Torr)§	42 ± 1	48 ± 1^†	54 ± 1^‡	41 ± 1	46 ± 1^*^†	52 ± 2^*^‡
pH_a	7.4 ± 0.0	7.4 ± 0.0	7.4 ± 0.0	7.4 ± 0.0	7.4 ± 0.0	7.4 ± 0.0
pH_v§	7.4 ± 0.0	7.4 ± 0.0	7.3 ± 0.0	7.4 ± 0.0	7.4 ± 0.0	7.3 ± 0.0

Values are means ±s.e.m.

Main effect of hypoxia, P < 0.05 vs. normoxia

^†

P <0.05 vs. rest

^‡

P < 0.05 vs. 10% exercise; § main effect of drug, P < 0.05 vs. control.