. 2007 Nov 29;586(Pt 4):1195–1205. doi: 10.1113/jphysiol.2007.144113

Table 3.

Venous noradrenaline and arterial adrenaline at rest and increasing exercise intensity during normoxia and hypoxia with each drug infusion

	Normoxia			Hypoxia

	Rest	10%	20%	Rest	10%	20%
Control (saline)
Arterial noradrenaline (pg ml⁻¹)	129 ± 14	116 ± 10	136 ± 13	141 ± 15^*	147 ± 17^*	149 ± 13^*
Venous noradrenaline (pg ml⁻¹)	176 ± 6	168 ± 4	180 ± 5	251 ± 9^*	203 ± 8^*^†	194 ± 6^*^†
v–a noradrenaline difference (pg ml⁻¹)	38 ± 12	35 ± 5	33 ± 7	99 ± 20^*	54 ± 12^*^†	35 ± 9^*^†
Arterial adrenaline (pg ml⁻¹)	43 ± 7	51 ± 5	49 ± 5	64 ± 9^*	73 ± 10^*	86 ± 18^*
Venous adrenaline (pg ml⁻¹)	16 ± 1	27 ± 1	38 ± 2	23 ± 1^*	52 ± 3^*^†	71 ± 5^*^†
Phentolamine
Arterial noradrenaline (pg ml⁻¹)	171 ± 16	167 ± 20	175 ± 21	179 ± 30	200 ± 26	214 ± 23
Venous noradrenaline (pg ml⁻¹)^§	282 ± 5	261 ± 11	248 ± 8	297 ± 13	270 ± 9	262 ± 10
v–a noradrenaline difference (pg ml⁻¹)	93 ± 12	79 ± 21	58 ± 11^†	85 ± 17	56 ± 8^†	57 ± 8^†
Arterial adrenaline (pg ml⁻¹)	42 ± 5	54 ± 6	60 ± 6	74 ± 10^*	76 ± 5^*	95 ± 15^*
Venous adrenaline (pg ml⁻¹)	27 ± 1	35 ± 1	45 ± 2	47 ± 3^*	53 ± 2^*^†	71 ± 4^*^†
Phentolamine/propranolol
Arterial noradrenaline (pg ml⁻¹)	176 ± 21	180 ± 21	192 ± 17	166 ± 19	167 ± 18	175 ± 20
Venous noradrenaline (pg ml⁻¹)^§	261 ± 9	277 ± 9	229 ± 7	258 ± 9	242 ± 9	217 ± 7
v–a noradrenaline difference (pg ml⁻¹)	78 ± 16	76 ± 10	42 ± 9^†	83 ± 14	68 ± 14	34 ± 18^†
Arterial adrenaline (pg ml⁻¹)^§^‡	67 ± 8	80 ± 9	98 ± 11^†	136 ± 20^*	163 ± 19^*^†	167 ± 26^*^†
Venous adrenaline (pg ml⁻¹)^§^‡	47 ± 2	64 ± 4	76 ± 4^†	88 ± 5^*	123 ± 4^*^†	137 ± 8^*^†

Values are means ±s.e.m.

Main effect of hypoxia, P < 0.05 vs. normoxia

^†

P < 0.05 vs. rest

^§

main effect of drug, P < 0.05 vs. control

^‡

main effect of drug, P < 0.05 vs. phentolamine.