Figure 7. Glycogen breakdown does not contribute to evoked rises in extracellular lactate.

Extracellular lactate rises in live rat cerebellum evoked by stimulation was unaffected by topical application of DAB, a glycogen phosphorylase inhibitor. A, original data from one animal illustrating lactate responses under control conditions and following application of DAB. The green forest of peaks below this correspond to the raw lactate levels, the red dotted lines indicate the start and end of stimulation. DAB did not alter the baseline and the stimulated lactate increase remained unchanged following DAB. B, histogram showing effect of DAB on lactate response. Data are mean ±s.e.m. (n = 5 in 3 animals) of lactate increase for the control and DAB stimuli. DAB readings were taken from stimulations after 1.5 h of drug application. P values are calculated as a result of paired Student's t tests between individual values of the same animal.