Figure 9. Dependence of NCX_mito model on Na⁺_c and Ca²⁺_c.

A, a scheme of NCX_mito model. B, linear relations between Na⁺_c and Na⁺_mito at intact (grey) and depolarized (black) ΔΨ_mito reproduced from Jung et al. (1992). C, Na⁺_c dependence of Ca²⁺ efflux via forward mode of NCX_mito. The continous line is a model simulation (Na⁺_mito= Na⁺_c/8.6 mm, Ca²⁺_mito= 300 nm, Ca²⁺_c= 0 and ΔΨ_mito=−180 mV). Circles are experimental data from Fig. 4B in the present study. D, Ca²⁺_c dependence of Ca²⁺ influx via reverse mode of NCX_mito. The continous line is a model simulation (Na⁺_mito= 25 mm, Na⁺_c= 0, Ca²⁺_mito= 0 and ΔΨ_mito= 0 mV). Circles are experimental data by Paucek & Jabůrek (2004).