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. 2007 May;210(5):532–541. doi: 10.1111/j.1469-7580.2007.00719.x

Fig. 1.

Fig. 1

Transverse sections through the optic vesicle of control, RA-treated or irradiated mouse embryos. Immunohistochemical staining with anti-caspase-3. (A) E9+12 C57Bl/6J control embryo. Caspase-3-positive cells (arrow) are seen in the optic vesicle, peri-optical mesectoderm and diencephalon. (B) E9+12, C57Bl/6J RA-treated embryo. We observe an increase of caspase-3-positive cells (arrow) in the optic vesicle. (C) E9+6 NMRI control embryo. Numerous caspase-3-positive cells (arrow) are seen in the central and ventral portion of the optic vesicle. Some caspase-3-positive cells are also seen in the lens placode. (D) E9+3 NMRI irradiated embryo. Caspase-3-positive cells (arrow) are increased in the optic vesicle, optic stalk and peri-optical mesectoderm. Fewer caspase-3-positive cells are seen within the lens placode.