Fig. 4.

Relationship between Lewy pathology and PD. (A) When Lewy pathology in each olfactory region is compared with the diagnosis of PD, it is apparent that pathology in the olfactory bulb occurs prior to clinical diagnosis of PD. (B) Comparison of Lewy pathology with PD diagnosis shows that a diagnosis of PD becomes more likely if Lewy pathology is present in the higher olfactory regions.