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. Author manuscript; available in PMC: 2008 May 13.
Published in final edited form as: J Biol Chem. 2001 Mar 14;276(21):17699–17705. doi: 10.1074/jbc.M009196200

FIG. 8. Glycine transporter inactivation by MTSET is reversed by DTE.

FIG. 8

(A) representative traces of glycine (100 μM) evoked current for GlyT1b (a–c) and GlyT2a-A223C (d–f) recorded in control Ringer (a, d), after 5 minutes applications of MTSET (1 mM) in cholineCl Ringer (b, e) and after 5 minutes application of DTE (10 mM) in cholineCl Ringer (c, f). The dotted line represents the initial baseline level. (B) Representative experiment with GlyT2-A223C showing the baseline current (○) and the steady-state glycine evoked current (▲) recorded every minute for a 10 s application of glycine (100 μM). No current were recorded during the application of MTSET and DTE in cholineCl Ringer. (C) Normalized glycine uptake current in control NaCl Ringer (open bar), after 5 minutes application of 1 mM MTSET (closed bar) or after 5 minutes application of 10 mM DTE (gray bar).

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