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. Author manuscript; available in PMC: 2009 Apr 4.
Published in final edited form as: J Mol Biol. 2008 Feb 4;377(4):1216–1227. doi: 10.1016/j.jmb.2008.01.082

Figure 8.

Figure 8

Effects of loop 1 mutations in α-RgIA. Single amino acid substitutions were made in the first loop of RgIA and the resulting analogues were tested on α7 and α9α10 nAChRs expressed in oocytes. (A) The left panel shows the concentration dependence of block of α9α10 nAChRs by wild type α-RgIA and analogues. Error bars are the standard error of the mean for at least three repetitions. The right panel shows IC50 values of wild-type α-RgIA and analogues against α9α10 nAChRs. The error bars are the 95% confidence interval. (B) As for (A) except that block of α7 nAChRs is shown. The IC50 and Hill slopes for all inhibition curves are in Table S3.