Table 2.
Changes in serum ferritin levels in thalassemia major patients treated with deferiprone
| Study | Number of enrolled | Dose | Length of study | Mean serum ferritin (μg/L) | |
|---|---|---|---|---|---|
| patients | (mg/kg/d) | (months) | First | Last | |
| Al-Refaie et al 1992 | 11 | 185–119 | 6–12 | 5549 | 4126 |
| Kersten et al 1996 | 36 | 50–100 | 1 to 36 | 3563 | 2560 |
| Mazza et al 1998 | 29 | 70 | >12 | 3748 | 2550 |
| Olivieri et al 1998 | 18 | 75 | 55.2 | 4455 | 2831 |
| Hoffbrand et al 1998 | 26 | 75 | 4 to 49 | 2937 | 2323 |
| Maggio et al 2002 | 71 | 75 | 12 | 2283 | 2061 |
| Rombos et al 2000 | 11 | 75–100 | 12 | 4732 | 3849 |
| Peng et al 2003 | 11 | 75 | 36 | 4652 | 2792 |
| Lucas et al 2002 | 54 | 75 | 9 | 5743 | 3558 |
| Taher et al 2004 | 12 | 75 | 60 | 4302 | 2229 |
| Cohen et al 2000 | 187 | 75 | 12 | 2696 | 2633 |
| Cohen et al 2003 | 84 | 75 | 48 | 2696 | 2889 |