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. 2002 Jul 2;87(2):218–224. doi: 10.1038/sj.bjc.6600430

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Copyright © 2002 Cancer Research UK

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Delineation of common region of deletion on chromosomal arm 14q in astrocytic tumors. Fourteen polymorphic loci, with their respective genetic intervals in centiMorgan (cM), were examined for allelic loss. Two common regions of deletion (thick bars) are identified: 14q22.3-32.1 and 14q32.1-qter. Filled circle represents loss of heterozygosity and open circle denotes retention of heterozygosity. Dash line indicates homozygosity. The candidate tumour suppressor gene, MLH3, is located between markers D14S258 and D14S74 on the genetic map.