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MC1R is overexpressed on melanomas and low expressed in in vitro cultured melanocytes. Melanoma, normal melanocytes cells and control COS7 cells were cultured on an objective glass overnight, carefully washed with PBS and then fixed with methanol. The fixed cells were stained with mAb MP1-1B7 or IgG control followed by a biotinylated anti-Ig mAb and developed as described in Materials and Methods. (A and B) Normal melanocytes, (C) FM55 melanoma line, and (D) FMS melanoma line.
