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. 2002 Oct 7;87(8):909–917. doi: 10.1038/sj.bjc.6600541

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Copyright © 2002 Cancer Research UK

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Staurosporine induced PARP cleavage in MCF-7 and T47D cells. Both (A) MCF-7 and (B) T47D cells were either treated with 1 μM STS for the times indicated or pre-incubated with 100 μM z-VAD-fmk for 1 h prior to STS treatments. Cell lysates (40 μg protein) were prepared and samples subjected to 8% SDS–PAGE followed by Western transfer and probed with PARP antibody (full length protein is 113 kDa, and cleaved fragment is 85 kDa). The results are representative of three independent experiments.