Figure 2.

BAG-1 binding partners and functions. BAG-1 interaction partners are indicated. Some of these interactions are direct, whereas others are probably mediated via binding to chaperone molecules, e.g., NHR. Interactions of BAG-1 with chaperones, E3 ligases and the proteasome suggest a key role in regulating the ubiquitin/proteasomal degradation system. Biological activities ascribed to BAG-1 are indicated below along with some potential molecular targets that might contribute to these effects. However, it is important to note that definitive evidence linking specific BAG-1 target molecules to biological responses is often lacking.