Skip to main content
. 2008 May 16;283(20):13565–13577. doi: 10.1074/jbc.M708916200

FIGURE 10.

FIGURE 10.

JNK inhibitor given after APAP treatment still partially protects against JNK-induced mitochondria dysfunction. A, protective effects of JNK inhibitor treatment following APAP administration in C57BL/6 mice. ▴, APAP; ▪, APAP plus JNK inhibitor. Mice received either JNK inhibitor or vehicle (DMSO-PBS) at time points indicated following APAP treatments. Serum ALT levels were measured 24 h after APAP. B, effect of delaying JNK inhibitor (2 h following APAP) on JNK activation and translocation to mitochondria (at 4 h following APAP). C, effect of delaying JNK inhibitor (2 h following APAP) on mitochondria state III respiration (at 4 h following APAP treatment). Mitochondria respiration was measured using an oxygen electrode in the presence of complex I substrate (glutamate/malate) plus ADP. Results are mean ± S.D. *, p < 0.05 versus APAP treatment alone. n = 4 mice.