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. 2008 May 16;283(20):14100–14108. doi: 10.1074/jbc.M801357200

FIGURE 2.

FIGURE 2.

IL-17RA is induced by IL-15 and IL-21 but not by IL-2. A, IL-2 dominantly suppresses IL-17RA surface expression mediated by IL-15 and IL-21. HT-2 cells were treated for 24 h with the indicated cytokines, and IL-17RA surface expression was assessed by flow cytometry. Filled histograms, isotype control. Average mean fluorescent intensity of IL-17RA expression relative to IL-2-treated cells was determined from five independent experiments (right panel). 2°, secondary Ab alone. B, IL-2 dominantly suppresses IL-17RA mRNA expression mediated by IL-15 and IL-21. HT-2 cells were treated for 24 h with the indicated cytokines, and IL-17RA mRNA levels were determined in triplicate by real-time RT-PCR. *, p < 0.05 compared with IL-2-treated control.