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The crystallographic tetramers of full-length recombinant BChE (a) are not mediated by the tetramerization domain as is the case in the cocrystal structure of the tetramerization domain of acetylcholinesterase with PRAD (b), PDB code 1vzj (Dvir et al., 2004 ▶), which instead has two monomers with C-termini oriented away from the other two monomers.
