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. 2003 Mar 4;88(5):733–739. doi: 10.1038/sj.bjc.6600777

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Copyright © 2003 Cancer Research UK

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Immunostaining for the M6P/IGF-2R on normal (A) and cirrhotic liver (B, HCV-related cirrhosis) with the IGF-receptor-2 antibody 2C2. Normal liver displays cytoplasmic and membrane-specific immunostaining of hepatocytes (A). Cirrhosis related to HCV infection shows reduced immunostaining of hepatocytes restricted to the sinusoidal part of the cell membrane as well as increased signals in perisinusoidal cells (B).