Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2003 Mar 4;88(5):733–739. doi: 10.1038/sj.bjc.6600777

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2003 Cancer Research UK

This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Immunostaining for the insulin receptor on normal (A) and cirrhotic liver (B) with monoclonal antibody CT-3, producing a membraneous staining without obvious differences between architecturally normal (A) and cirrhotic (B) liver. Immunostaining for the IGF-1R revealed a trophoblast epithelial staining pattern in mature placenta (C), and weak cytoplasmic and membraneous staining largely of hepatocytes in normal and cirrhotic liver (D). The IGFBP-3-specific monoclonal antibody reacted with sinusoidal cells on cirrhotic (E) and normal liver (F), part of which is morphologically compatible with Kupffer cells. Immunostaining for the IGFBP-4 on placenta for control (G) and cirrhotic liver (H) with the anti-human IGFBP-4 antibody. The IGFBP-4-specific antibody showed a clear cytoplasmatic staining in mature placenta (G), whereas cirrhotic liver displayed a weak immunoreactivity of cells also compatible with Kupffer cells.