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. 2003 Apr 1;88(7):1135–1142. doi: 10.1038/sj.bjc.6600814

Figure 4.

Figure 4

Time-dependent changes in signal enhancement (A) and R1p values (B) in dynamic contrast agent-enhanced T1-weighted images obtained from EL-4 (▴), progressive E.G7-OVA (▪) and regressive E.G7-OVA (•) tumours. R1p, the paramagnetic contribution to the relaxation rate, is equivalent to the contrast agent concentration. The symbols represent the mean±s.e.m. (n=5). The numbers for signal enhancement were obtained from the entire tumour cross-section. However, because of difficulties in estimating R1p values in the relatively poorly perfused regions in the centres of some tumours, these were calculated for a 20 pixel-wide band in the tumour peripheries, where vessel density was higher.