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. 2003 Apr 1;88(7):1135–1142. doi: 10.1038/sj.bjc.6600814

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Copyright © 2003 Cancer Research UK

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Time-dependent changes in signal enhancement in tumours using dynamic contrast-enhanced MRI with the macromolecular contrast BSA–Gd-DTPA. A series of T₁-weighted spin echo images were acquired from EL-4 (▴, n=7), progressive E.G7-OVA (▪, n=6) and regressive E.G7-OVA (•, n=2) tumours. The symbols and error bars show the mean±s.e.m. The values were calculated for a 20 pixel-wide band in the tumour peripheries, where vessel density was higher. The high molecular weight agent is initially confined to the vasculature, so the greater signal enhancement of regressive E.G7-OVA tumours is indicative of a higher functional vascular volume fraction.