Table 3. Prognostic factors related to axillary node invasion in early (T1) breast cancer: multivariate analysis including the interaction between uPA–PAI and positive progesterone receptors (PR+).
| OR | 95% CI | P-value | |
|---|---|---|---|
|
Tumour size | |||
| >1 cm | 1 | ||
| ⩽1 cm | 0.34 | 0.12–1.00 | 0.051 |
|
Hormone receptors and uPA–PAIa | |||
| ER− and PR− | 1 | 0.20–4.66 | 0.955 |
| ER+ and PR− | 0.96 | 0.04–2.29 | 0.199 |
| ER+ and PR+, and uPA–PAI negativea | 0.31 | 1.28–11.6 | 0.017 |
| ER+ and PR+, and uPA–PAI positivea | 3.85 | ||
|
Histologic grade | |||
| 1–2 | 1 | ||
| 3 | 2.56 | 0.90–7.27 | 0.077 |
|
Ki67 | |||
| ⩽10% | 1 | ||
| >10% | 2.09 | 0.76–5.75 | 0.154 |
|
CD44 | |||
| Positive | 1 | ||
| Negative | 6.86 | 2.69–17.5 | <0.001 |
a
The interaction term PR and uPA–PAI was statistically significant (P=0.032), but uPA–PAI complexes only showed any effect in PR+ tumours. The model was therefore adapted to consider this variable only among PR+ cases (see text).