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. 2003 Jan 28;88(1):96–101. doi: 10.1038/sj.bjc.6600656

Table 3. Prognostic factors related to axillary node invasion in early (T1) breast cancer: multivariate analysis including the interaction between uPA–PAI and positive progesterone receptors (PR+).

  OR 95% CI P-value
       
Tumour size
>1 cm 1    
⩽1 cm 0.34 0.12–1.00 0.051
       
Hormone receptors and uPA–PAIa
ER− and PR− 1 0.20–4.66 0.955
ER+ and PR− 0.96 0.04–2.29 0.199
ER+ and PR+, and uPA–PAI negativea 0.31 1.28–11.6 0.017
ER+ and PR+, and uPA–PAI positivea 3.85    
       
Histologic grade
1–2 1    
3 2.56 0.90–7.27 0.077
       
Ki67
⩽10% 1    
>10% 2.09 0.76–5.75 0.154
       
CD44
Positive 1    
Negative 6.86 2.69–17.5 <0.001
a

The interaction term PR and uPA–PAI was statistically significant (P=0.032), but uPA–PAI complexes only showed any effect in PR+ tumours. The model was therefore adapted to consider this variable only among PR+ cases (see text).