Table 3. Alcohol drinking and breast cancer risk for subjects with GSTT1-null genotype.
|
Premenopausal |
Postmenopausal |
|||
|---|---|---|---|---|
| Alcohol drinking | Ca/Coa | ORb (95% CI) | Ca/Coa | ORb (95% CI) |
| Never | 3/4 | 1.0 | 7/7 | 1.0 |
| Ever | 21/30 | 0.8 (0.1/4.9) | 64/33 | 2.3 (0.6/8.3) |
| Age when started drinking (y) | ||||
| <18 | 5/6 | 1.0 (0.1/9.9) | 9/3 | 3.2 (0.5/21.9) |
| 18–24 | 12/19 | 0.8 (0.1/5.0) | 40/22 | 2.4 (0.6/9.6) |
| >24 | 4/5 | 0.9 (0.1/8.0) | 15/8 | 1.8 (0.4/8.3) |
| P for trend | 0.82 | 0.99 | ||
| Spirit-equivalent drinking per day (g) | ||||
| <80 | 7/6 | 1.4 (0.2/11.7) | 12/7 | 1.9 (0.4/9.4) |
| 80–150 | 6/10 | 0.8 (0.1/6.1) | 30/16 | 2.2 (0.6/8.6) |
| >150 | 8/14 | 0.6 (0.1/4.1) | 22/10 | 3.1 (0.6/15.1) |
| P for trend | 0.64 | 0.18 | ||
| Years of drinking | ||||
| <15 | 6/8 | 1.2 (0.1/9.0) | 7/9 | 0.9 (0.2/5.0) |
| 15–30 | 15/18 | 1.2 (0.2/7.8) | 27/11 | 2.9 (0.6/13.1) |
| >30 | 0/4 | 30/13 | 2.6 (0.6/10.8) | |
| P for trend | 0.25 | 0.11 | ||
| Lifetime kilograms of spirit-equivalent drinking | ||||
| <70 | 8/11 | 0.9 (0.1/5.7) | 14/13 | 1.0 (0.2/4.7) |
| 70–250 | 8/8 | 1.1 (0.1/8.3) | 19/12 | 1.5 (0.3/7.3) |
| >250 | 5/11 | 0.6 (0.1/4.6) | 31/8 | 6.8 (1.4/33.9) |
| P for trend | 0.64 | 0.03 | ||
a
Cases/controls.
b
Adjusted for age, BMI (<21, 21–24, >24), age at first full-term pregnancy nulliparous (<20, 20–25, >25 y), lifetime duration of lactation (never, 1–5, 6–11, >11 months), family breast cancer history.