Table 3. Association of MMP-7+MMP-9 coexpression and clinicopathologic findings.
|
MMP-7+MMP-9 |
Invasive front MMP-7+MMP-9 |
|||||
|---|---|---|---|---|---|---|
| Positive | Others | P | Positive | Others | P | |
| Variables | (n=11) | (n=44) | value | (n=6) | (n=49) | value |
| Gender | ||||||
| Male | 10 | 31 | 0.255 | 5 | 36 | 1 |
| Female | 1 | 13 | 1 | 13 | ||
| Age | ||||||
| ≦59 | 1 | 15 | 0.341 | 1 | 15 | 0.863 |
| 60–64 | 4 | 5 | 2 | 7 | ||
| 65–69 | 3 | 7 | 2 | 8 | ||
| 70≦ | 3 | 17 | 1 | 19 | ||
| Gross features | ||||||
| Elevated | 4 | 7 | 0.158 | 2 | 9 | 0.134 |
| Flat | 1 | 1 | 1 | 1 | ||
| Depressed | 6 | 36 | 3 | 39 | ||
| Depth of invasion | ||||||
| EP | 0 | 9 | 0.008* | 0 | 9 | 0.025* |
| LPM | 0 | 6 | 0 | 6 | ||
| MM | 2 | 14 | 0 | 16 | ||
| SM | 9 | 15 | 6 | 18 | ||
| Differentiation grade | ||||||
| SCC (well) | 1 | 9 | 0.452 | 0 | 10 | 0.132 |
| SCC (moderately) | 8 | 23 | 6 | 25 | ||
| SCC (poorly) | 1 | 10 | 0 | 11 | ||
| Others | 1 | 2 | 0 | 3 | ||
| Lymphatic permeation | ||||||
| Positive | 7 | 14 | 0.082 | 5 | 16 | 0.026* |
| Negative | 4 | 30 | 1 | 33 | ||
| Venous invasion | ||||||
| Positive | 1 | 7 | 1 | 1 | 7 | 1 |
| Negative | 10 | 37 | 5 | 42 | ||
| Infiltrative growth pattern | ||||||
| α | 2 | 26 | 0.058 | 1 | 27 | 0.064 |
| β | 8 | 17 | 4 | 21 | ||
| γ | 1 | 1 | 1 | 1 | ||
| Nodal metastasis | ||||||
| Positive | 6 | 6 | 0.008* | 4 | 8 | 0.017* |
| Negative | 5 | 38 | 2 | 41 | ||
*
significant.