Table 1. Odds ratios (ORs) and 95% confidence intervals (CIs) for adenocarcinomas and squamous cell carcinomas of the cervix in relation to sexual behaviour and body weight.
|
Adenocarcinoma |
Squamous cell carcinoma |
Squamous vs adenocarcinoma |
|||||||
|---|---|---|---|---|---|---|---|---|---|
| Cases/controls | ORa | 95% CI | Cases/controls | ORb | 95% CI | Squamous/adeno cases | ORc | 95% CI | |
| Lifetime number of sexual partners | |||||||||
| 1 | 52/417 | 1.00 | 60/417 | 1.00 | 60/52 | 1.00 | |||
| 2–4 | 84/330 | 1.96 | 1.31–2.93 | 186/330 | 3.31 | 2.34–4.70 | 186/84 | 1.65 | 1.00–2.73 |
| 5+ | 44/176 | 1.98 | 1.21–3.26 | 145/176 | 4.09 | 2.75–6.08 | 145/44 | 1.78 | 1.00–3.18 |
| Trend test | P=0.1 | P<0.0001 | P=0.3 | ||||||
| Lifetime number of regular sexual partners (3+ months)a | |||||||||
| 0 or 1 | 63/499 | 1.00 | 91/499 | 1.00 | 91/63 | 1.00 | |||
| 2 | 60/223 | 1.97 | 1.29–3.02 | 111/223 | 2.30 | 1.62–3.27 | 111/60 | 1.01 | 0.61–1.67 |
| 3+ | 57/201 | 2.18 | 1.36–3.47 | 189/201 | 3.40 | 2.38–4.86 | 189/57 | 1.63 | 0.97–2.71 |
| Trend | P=0.003 | P<0.0001 | P=0.03 | ||||||
| Lifetime number of nonregular sexual partnersb | |||||||||
| 0 | 101/603 | 1.00 | 170/603 | 1.00 | 170/101 | 1.00 | |||
| 1–4 | 66/251 | 1.26 | 0.85–1.87 | 163/251 | 1.39 | 1.02–1.89 | 163/66 | 1.09 | 0.70–1.70 |
| 5+ | 13/69 | 0.75 | 0.37–1.52 | 58/69 | 1.29 | 0.80–2.07 | 58/13 | 1.28 | 0.60–2.75 |
| Trend | P=0.3 | P=0.5 | P=0.5 | ||||||
| Age at first intercourse (years) | |||||||||
| 20+ | 32/283 | 1.00 | 42/283 | 1.00 | 42/32 | 1.00 | |||
| 18–19 | 57/297 | 1.41 | 0.86–2.32 | 103/297 | 1.43 | 0.93–2.20 | 103/57 | 1.03 | 0.55–1.92 |
| ⩽17 | 91/343 | 2.01 | 1.23–3.30 | 246/343 | 2.70 | 1.78–4.11 | 246/91 | 1.38 | 0.75–2.55 |
| Trend | P=0.004 | P<0.0001 | P=0.2 | ||||||
| Weight at reference age (kg)c | |||||||||
| <55 | 52/289 | 1.00 | 141/289 | 1.00 | 141/52 | 1.00 | |||
| 55–64 | 82/359 | 1.25 | 0.84–1.86 | 151/359 | 0.95 | 0.70–1.30 | 151/82 | 0.71 | 0.45–1.13 |
| 65+ | 45/273 | 1.00 | 0.63–1.57 | 99/273 | 0.85 | 0.61–1.20 | 99/45 | 0.90 | 0.54–1.52 |
| Trend | P=0.7 | P=0.4 | P=0.8 | ||||||
| Body mass index at reference agec | |||||||||
| Normal (20–24.9) | 104/540 | 1.00 | 228/540 | 1.00 | 228/104 | 1.00 | |||
| Overweight/obese (25+) | 40/219 | 0.98 | 0.64–1.49 | 78/219 | 0.87 | 0.62–1.23 | 78/40 | 0.89 | 0.55–1.46 |
| Underweight (<20) | 35/162 | 1.16 | 0.74–1.81 | 85/162 | 1.11 | 0.79–1.55 | 85/35 | 0.90 | 0.54–1.49 |
ORa, odds ratio for adenocarcinoma vs controls; ORb, odds ratio for squamous cell carcinoma vs controls; ORc, odds ratio for squamous cell carcinoma cases vs adenocarcinoma cases; all adjusted for age, region, smoking, duration of oral contraceptive use, number of negative screening results and education and adjusted as appropriate for total number of sexual partners and age at first intercourse.
a
Adjusted for nonregular partners instead of total partners.
b
Adjusted for regular partners instead of total partners.
c
Reference age=age 1 year before diagnosis (cases) or pseudodiagnosis (controls).