Table 2. Odds ratios (ORs) and 95% confidence intervals (CIs) for adenocarcinomas and squamous cell carcinomas of the cervix in relation to reproductive factors.
Adenocarcinoma |
Squamous cell carcinoma |
Squamous vs adenocarcinoma |
|||||||
---|---|---|---|---|---|---|---|---|---|
Cases/controls | ORa | 95% CI | Cases/controls | ORb | 95% CI | Squamous/adeno cases | ORc | 95% CI | |
Ever given birth | |||||||||
Never | 21/150 | 1.00 | 60/150 | 1.00 | 60/21 | 1.00 | |||
Ever | 159/773 | 1.24 | 0.72–2.14 | 331/773 | 1.26 | 0.85–1.86 | 331/159 | 1.09 | 0.58–2.04 |
Total number of live births | |||||||||
0 | 21/150 | 1.00 | 60/150 | 1.00 | 60/21 | 1.00 | |||
1 | 38/176 | 1.27 | 0.69–2.34 | 62/176 | 0.88 | 0.55–1.40 | 62/38 | 0.73 | 0.36–1.49 |
2 | 65/377 | 1.14 | 0.63–2.05 | 145/377 | 1.41 | 0.92–2.17 | 145/65 | 1.33 | 0.67–2.63 |
3+ | 56/220 | 1.44 | 0.76–2.73 | 124/220 | 1.86 | 1.16–2.99 | 124/56 | 1.47 | 0.70–3.11 |
Trend | P=0.3 | P=0.001 | P=0.1 | ||||||
Time since last birth | |||||||||
Never | 21/150 | 1.00 | 60/150 | 1.00 | 60/21 | 1.00 | |||
⩽10 years | 77/468 | 1.13 | 0.65–1.99 | 219/468 | 1.30 | 0.88–1.94 | 219/77 | 1.24 | 0.65–2.37 |
10+ years | 82/305 | 1.63 | 0.86–3.07 | 112/305 | 1.07 | 0.66–1.73 | 112/82 | 0.66 | 0.32–1.40 |
Heterogeneity between groups within parous women | P=0.2 | P=0.3 | P=0.03 | ||||||
Age at first birth | |||||||||
Never | 21/150 | 1.00 | 60/150 | 1.00 | 60/21 | 1.00 | |||
25+ years | 36/272 | 0.92 | 0.49–1.70 | 70/272 | 0.94 | 0.60–1.47 | 70/36 | 1.07 | 0.52–2.18 |
20–24 years | 63/322 | 1.40 | 0.77–2.55 | 108/322 | 1.23 | 0.79–1.91 | 108/63 | 1.04 | 0.51–2.11 |
15–19 years | 60/179 | 1.71 | 0.89–3.29 | 153/179 | 2.01 | 1.26–3.21 | 153/60 | 1.16 | 0.57–2.38 |
Trend within parous women | P=0.03 | P=0.002 | P=0.7 | ||||||
Number of interrupted pregnancies | |||||||||
0 | 126/647 | 1.00 | 239/647 | 1.00 | 239/126 | 1.00 | |||
1+ | 54/276 | 0.91 | 0.63–1.31 | 152/276 | 1.16 | 0.88–1.54 | 152/54 | 1.36 | 0.89–2.08 |
ORa, odds ratio for adenocarcinoma vs controls; ORb, odds ratio for squamous cell carcinoma vs controls; ORc, odds ratio for squamous cell carcinoma vs adenocarcinoma cases; all adjusted for age, region, total number of sexual partners, age at first intercourse, smoking, duration of oral contraceptive use, number of negative screening results and education.