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. 2003 Aug 12;89(4):691–696. doi: 10.1038/sj.bjc.6601075

Table 5. Relation between Arg462Gln and Asp541Glu gennotypes and the number of affected family members.

  No. of subjects (%)
   
  No. of affected members
   
Genotype <2 >2 OR (95% CI) P-value
Arg462Gln        
 Arg/Arg 49 (68.1%) 20 (69.0%) 1.0 (Ref.)  
 Arg/Gln 23 (31 9%) 9 (31.0%) 0.96 (0.55–1.67) 0.93
 Gln/Gln 0 (0.0%) 0 (0.0%)    
         
Asp541Glu        
 Glu/Glu 37 (51.4%) 14 (48.3%) 1.0 (Ref.)  
 Glu/Asp 26 (36.1%) 6 (20.7%) 0.61 (0.35–1.06) 0.37
 Asp/Asp 9 (12.5%) 9 (31.0%) 2.64 (1.52–4.61) 0.08
         
 Glu/Glu+Glu/Asp 63 (87.5%) 20 (69.0%) 1.0 (Ref.)  
 Asp/Asp 9 (12.5%) 9 (31.0%) 3.15 (1.81–5.49) 0.028