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. 2003 Aug 12;89(4):754–762. doi: 10.1038/sj.bjc.6601162

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Copyright © 2003 Cancer Research UK

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Normalised growth curves (relative tumour volume: mean±s.d.) for s.c. implanted colon carcinoma C26-B and C26-10 in Balb/C mice after i.p. bolus treatment with 150 mg kg⁻¹ 5-FU alone (C26-B, n=9; C26-10, n=11) or in combination with 9.5-min carbogen breathing (C26-B, n=11; C26-10, n=10). Two-way ANOVA indicates that differences between tumour variants are highly significant with or without carbogen: group 1 vs 3, P=0.02; group 2 vs 4, P=0.003. A significant effect of carbogen was observed only for the more slowly growing, 5-FU-sensitive C26-10 tumours: group 1 vs 2, P=0.35; group 3 vs 4, P=0.03.