Table 3. Grade 3–4 adverse events classified according to NCI-CTC.
|
Patients (N=40) N (%) |
Cycles (163) n (%) |
|||||
|---|---|---|---|---|---|---|
| Grade 3–4 NCI/CTC adverse events | Grade 3 | Grade 4 | 3+4 | Grade 3 | Grade 4 | 3+4 |
| Anaemiaa | 4 | 1 | 5 (12.8) | 5 | 1 | 6 (3.7) |
| Leucopeniaa | 5 | 6 | 11 (28.2) | 11 | 7 | 18 (11.2) |
| Neutropeniaa | 7 | 8 | 15 (38.5) | 13 | 13 | 26 (16.5) |
| Thrombocytopeniaa | — | 2 | 2 (5.1) | — | 2 | 2 (1.2) |
| Febrile neutropenia | 5 | — | 5 (12.5) | 6 | — | 6 (3.7) |
| Infection with concomitant gr3–4 neutropenia | 1 | — | 1 (2.5) | 1 | — | 1 (0.6) |
| Diarrhoea | 5 | 3 | 8 (20.0) | 6 | 3 | 9 (5.5) |
| Asthenia | 4 | — | 4 (10.0) | 4 | — | 4 (2.5) |
| Nausea | 3 | — | 3 (7.5) | 3 | — | 3 (1.8) |
| Vomiting | 2 | — | 2 (5.0) | 2 | — | 2 (1.2) |
| Abdominal pain | 1 | 1 | 2 (5.0) | 1 | 1 | 2 (1.2) |
a
N=39 evaluable patients (with at least one blood count).
n=161 evaluable cycles (with at least one blood count) except for neutropenia (n=158 cycles).