Fig. 2.
Schematic diagram of an aspiny cholinergic neuron (ASpN) and its projections to convergent sites of glutamatergic and dopaminergic input on striatal GABAergic medium spiny projection neurons (MSpN). Changes in local [ACh], from pauses in the firing of these TANS, modulate the net output of the striatum by interactions with ACh receptors and binding sites in pre-, post-, and perisynaptic compartments.