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. Author manuscript; available in PMC: 2008 May 12.
Published in final edited form as: Nat Immunol. 2007 Dec 2;9(1):89–96. doi: 10.1038/ni1550

Figure 6. Reconstitution of CRACM1-/- mast cells with WT-CRACM1 reverses the defect in degranulation.

Figure 6

Serotonin release from CRACM1-/- mast cells reconstituted with WT-CRACM1 expressing retrovirus (CRACM1-MIGW) or empty vector (MIGW). CRACM1+/+, +/- and the reconstituted -/- mast cells were stimulated with PMA (1.5μg/ml) plus Ionomycin (2μM) for 20 min. Results are expressed as percentage of total serotonin uptake.