Table 2. Number of cureda tumours per treatment group for light doses of 5–30 J cm−2 applied at various intervals after one or two doses of Foscan.
|
Drug–light interval |
|||||||||
|---|---|---|---|---|---|---|---|---|---|
| Drug dose (mg kg−1) | Light dose (J cm−2) | 5 min | 20 min | 1 h | 3 h | 6 h | 24 h | 48 h | 72 h |
| 1×0.3 | 5 | — | 0/8 | 0/8 | 1/8 | 0/8 | 0/8 | — | — |
| 1×0.3 | 10 | — | 1/8 | 1/8 | 4/8 | 4/8 | 0/8 | — | — |
| 1×0.3 | 30 | 1/8 | 2/8 | 3/7b | 8/8 | 5/8 | 0/8 | 0/8 | 0/8 |
| 2×0.3 | 30 | 1/8 | 1/8 | 5/7 | 3/8 | 5/7 | 1/7 | 0/8 | 0/8 |
a
No palpable tumour at 120 days after treatment time.
b
This group also included three tumours that did not regrow, but mice were sacrificed with lung metastases before the cure end point time of 120 days.