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. 2003 Jan 28;88(2):291–297. doi: 10.1038/sj.bjc.6600680

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Copyright © 2003 Cancer Research UK

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(A) Left: Bioscope image of an R-18 tumour. ^99mTc-HSA was administered intravenously to the tumour-bearing mouse. The mouse was killed and the tumour was frozen in liquid nitrogen 1 min after the administration of ^99mTc-HSA. The concentration of ^99mTc-HSA in the tumour tissue is proportional to the intensity in the Bioscope image. Right: histological image of the tumour region demarcated with red lines in the Bioscope image. Low-pass-filtered Bioscope image, showing the concentration of ^99mTc-HSA in green, is superimposed on the histological image. (B) Left: Bioscope image of an R-18 tumour. ^99mTc-HSA was administered intravenously to the tumour-bearing mouse. The mouse was killed and the tumour was frozen in liquid nitrogen 60 min after the administration of ^99mTc-HSA. The concentration of ^99mTc-HSA in the tumour tissue is proportional to the intensity in the Bioscope image. Right: histological image of the same tumour section. Low-pass-filtered Bioscope image, showing the concentration of ^99mTc-HSA in green, is superimposed on the histological image. (C) Histological image of a D-12 tumour. Low-pass-filtered Bioscope image, showing the concentration of ^99mTc-HSA in green, is superimposed on the histological image. ^99mTc-HSA was administered intravenously to the tumour-bearing mouse. The mouse was killed and the tumour was frozen in liquid nitrogen 180 min after the administration of ^99mTc-HSA. Necrotic regions are indicated by N.