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. 2003 Jan 28;88(2):291–297. doi: 10.1038/sj.bjc.6600680

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Copyright © 2003 Cancer Research UK

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Extracellular volume fraction vs distance from tumour centre in A-07 and R-18 tumours. ^99mTc-HSA was administered intravenously to tumour-bearing mice with ligated renal arteries. The mice were killed and the tumours were frozen in liquid nitrogen 3 h after the administration of ^99mTc-HSA. The concentration of ^99mTc-HSA in the tumour tissue was used as a parameter for extracellular volume fraction. Tumour size was normalised, that is, tumour radius was assigned a value of 1.0. Extracellular volume fraction was also normalised, that is, the mean concentration of ^99mTc-HSA in each tumour section was assigned a value of 1.0. One section was analysed for each tumour. Points represent mean values of 8 (A-07) or 7 (R-18) tumours. Bars represent s.e.m.