Table 3. Cox proportional hazards regression analysis for 56 patients with prostate cancer with bone metastasis.
|
Univariate |
Multivariate |
|||||
|---|---|---|---|---|---|---|
| Variable | Cutoffsa | P-value | Relative risk ratio | 95% CIb | P-value | Relative risk ratio |
| %PABS (%) | 4.6 or greater/less than 4.6 | 0.016 | 2.603 | 1.199–5.651 | 0.016 | 2.603 |
| Serum alkaline phosphatase (IUl−1) | 467 or greater/less than 467 | 0.027 | 2.452 | 1.016–5.434 | — | — |
| No. of bone lesions | 14 or greater/less than 14 | 0.044 | 2.222 | 1.024–4.824 | — | — |
| Tumour grade on biopsy | Poorly/well or moderately | 0.044 | 2.153 | 1.021–4.540 | — | — |
| Serum ICTP (ngml−1) | 6.1 or greater/less than 6.1 | 0.103 | 1.906 | 0.878–4.136 | — | — |
| EOD grade | 3 or 4/1or2 | 0.104 | 1.868 | 0.879–3.970 | — | — |
| Patient's age (years) | 72 or greater/less than 72 | 0.326 | 1.462 | 0.685–3.119 | — | — |
| Serum PSA (ngml−1) | 220 or greater/less than 220 | 0.361 | 1.430 | 0.664–3.079 | — | — |
| EOCG performance status | 1 or 2 or 3/0 | 0.474 | 1.426 | 0.540–3.767 | — | — |
a
%PABS, alkaline phosphatase, number of bone lesions, ICTP, patient age and PSA are based on median values, and the remaining are treated as dichotomous variables.
b
Confidence intervals. Of the 56 patients, 28 (50%) had cancer death.