Table 1. Percent distributions of the genotypes and pairwise linkage disequilibrium scores for three markers in the TH-INS-IGF2 region stratified by ethnicity.
All racesa |
Black |
Caucasian |
Hispanic |
|||||
---|---|---|---|---|---|---|---|---|
Cases | Controls | Cases | Controls | Cases | Controls | Cases | Controls | |
N=178 (%) | N=135 (%) | N=96 (%) | N=67 (%) | N=40 (%) | N=36 (%) | N=37 (%) | N=29 (%) | |
+1127 INS-PstI | ||||||||
CC | 80 | 70 | 81 | 72 | 80 | 61 | 73 | 79 |
CT | 18 | 26 | 18 | 27 | 17 | 33 | 24 | 10 |
TT | 2 | 4 | 1 | 1 | 3 | 6 | 3 | 10 |
−4217 TH-PstI | ||||||||
CC | 13 | 17 | 8 | 5 | 25 | 33 | 14 | 25 |
CT | 43 | 31 | 39 | 20 | 47 | 42 | 43 | 36 |
TT | 44 | 52 | 53 | 75 | 28 | 25 | 43 | 39 |
+3580 IGF2-MspI | ||||||||
GG | 42 | 42 | 50 | 37 | 25 | 49 | 41 | 50 |
AG | 40 | 46 | 37 | 53 | 55 | 41 | 32 | 37 |
AA | 18 | 11 | 13 | 10 | 20 | 10 | 27 | 13 |
Linkage disequilibrium score (D′)b | ||||||||
+1127 INS-PstI and −4217 TH-PstI | 0.76 | 1 | 1 | |||||
+1127 INS-PstI and +3580 IGF2-MspI | 0.85 | 0.80 | 0.87 | |||||
−4217 TH-PstI and +3580 IGF2-MspI | 0.49 | 0.45 | 0.31 |
Subjects with mixed ethnicity were included here, but not in the race-specific columns.
D′ was determined with cases and controls combined.