Table 2. Odds ratios for the association between prostate cancer and the homozygous CC genotype of +1127 INS-PstI.
| No of pairs | OR (95% CI)a | P-value | |
|---|---|---|---|
| All subjects | 126 | 1.74 (0.99–3.05) | 0.055 |
| By diabetes status | |||
| No | 86 | 2.18 (1.07–4.45) | 0.032 |
| Yesb | 40 | 1.13 (0.43–2.92) | 0.809 |
| By race, among nondiabetics | |||
| Black | 45 | 2.75 (0.88–8.64) | 0.083 |
| Caucasian | 26 | 3.67 (1.02–13.14) | 0.046 |
| Hispanic | 14 | 0.25 (0.03–2.24) | 0.215 |
| Black and Caucasian, among nondiabetics | 71 | 3.14 (1.34–7.36) | 0.008 |
| By age, among nondiabetic Black and Caucasianc | |||
| <55 | 14 | 0.75 (0.17–3.35) | 0.706 |
| ⩾55 | 57 | 6.33 (1.87–21.4) | 0.003 |
a
Odds ratios for the risk of prostate cancer when subjects with homozygous CC were compared with those with other genotypes (the heterozygous and homozygous TT), with the latter as the reference group.
b
One or both members of the pair had diabetes.
c
The case's age at diagnosis was used for classification of the pair. P-value for homogeneity of odds ratios (i.e. interaction between age and the +1127 INS-PstI polymorphism)=0.030.