Table 3. Associations between prostate cancer and three markers in the TH-INS-IGF2 genomic region – among non-diabetic Black and Caucasian subjects (n=68 pairs).
| Adjusted OR (95% CI)a | P | |
|---|---|---|
| +1127 INS-PstI | ||
| CT or TT | 1 | |
| CC | 3.57 (1.35–9.45) | 0.010 |
| −4217 TH-PstI | ||
| TT | 1 | |
| CT | 2.27 (0.99–5.19) | 0.053 |
| CC | 1.72 (0.55–5.42) | 0.355 |
| +3580 IGF2-MspIb | ||
| GG | 1 | |
| AG | 0.90 (0.42–1.95) | 0.797 |
| AA | 1.52 (0.37–6.27) | 0.559 |
a
Odds ratios were adjusted for the other two markers in the model.
b
IGF2 is subject to parental imprinting, and only the paternal allele is expressed. OR for the heterozygous genotype was difficult to interpret, when the expressing allele (A or G) was not identified. Conversely, knowing the active allele among the subjects with homozygous AA or GG was irrelevant. Hence, the OR for the homozygous AA was fully interpretable when the homozygous GG was used as the reference.