Table 1.

Summary of key findings on hepatic injury and mitochondrial oxidant stress/peroxynitrite formation in C3Heb/FeJ mice

	Control	1 h APAP	3 h APAP	6 h APAP	REFERENCES
Necrosis	−−	−−	++	+++	Knight et al., 2001, 2002; Gujral et al., 2002; Bajt et al., 2003
mGSH	+++	−−	+	++	Knight et al., 2001, 2002
mGSSG	(+)	−−	+	++	Knight et al., 2001, 2002
mNT	−−	+	++	++	Cover et al., 2005
MDNA	+++	+++	++	+	Cover et al., 2005

Mitochondrial oxidant stress and peroxynitrite formation in C3Heb/FeJ mice after 300 mg/kg acetaminophen (APAP) as published in previous papers. Symbols: −−, not detectable; (+) +, minor increases; ++ and +++ progressive higher levels/content of analyte in tissue. Abbreviations: mGSH, mitochondrial glutathione; mGSSG, mitochondrial glutathione disulfide; mNT, mitochondrial nitrotyrosine protein adducts; mDNA, intact mitochondrial DNA.