A) Model simulation of total energy expenditure, TEE, in response to imposed changes of metabolizable energy intake, MEI, during the Minnesota experiment. B) Simulated components of total energy expenditure including resting metabolic rate, RMR, physical activity expenditure, PAE, and the thermic effect of feeding, TEF. The experimental RMR measurements (□) are also shown. A few RMR data points do not have error bars since the uncertainties for these values were unreported.