Figure 5.

Tumour blood flow after ZnPP IX or L-NAME treatment. Tumour blood flow was measured in AH136B solid tumour on day 14 after tumour implantation. At the indicated times after injection of 500 μg kg⁻¹ ZnPP IX (i.a.) or 6 mg kg⁻¹ L-NAME (i.p.), a laser Doppler flowmeter and a probe needle were used to measure blood flow. Relative changes in tumour blood flow after injection of ZnPP IX or L-NAME are shown. Inset, change in tumour blood flow during early period after treatment (within 25 min). ^**P<0.01 by ANOVA between the groups (n=3 for each time point). Data are means±s.e. See text for details.