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. 2003 Mar 18;88(6):832–838. doi: 10.1038/sj.bjc.6600819

Table 1. Breast cancer tumour characteristics of women with cosmetic silicone breast implants prior to cancer diagnosis (cases) and breast cancer cases from the background population (controls).

  Cases (n=23)
 Controls (n=253)
  
Characteristic of woman or tumour n % n % OR (95% CI)a
Tumour histology (WHO)          
 Ductal 16 70 212 84 0.5 (0.2–1.6)b
 Lobular 5 22 18 7 P=0.26
 Other 0 0 18 7  
 Unknown 2 9 5 2  
           
Tumour hormone-receptor status          
 Negative 6 26 52 21 1.7 (0.6–4.9)
 Positive 10 43 148 59 P=0.32
 Unknown 7 30 53 21  
           
Tumour diameter (mm) (mean, range) 20.5 Range 9–50 25.2 Range 3–110 P=0.48
 Unknown 3 13 10 4  
           
Ductal carcinomas, malignancy grade (dedifferentiation)          
 Grade I 6 26 52 21 1.7 (0.6–5.0)c
 Grade II 9 39 110 43 P=0.31
 Grade III 1 4 40 16  
 Nonductal or unknown 7 30 51 20  
           
Breast cancer operation          
 Mastectomy 15 65 184 73 0.6 (0.3–1.6)d
 Lumpectomy 6 26 60 24 P=0.34
 Lumpectomy followed by mastectomy 0 0 4 2  
 Biopsy only 2 9 5 2  
           
Tumour cells in surgical margins (DBCG-data)          
 Yes 7 30 24 9 4.2 (1.5–11.4)
 No 14 61 201 79 P=0.003
 Unknown 2 9 28 11  
           
Tumour cells in surgical margins (medical record information)e          
 Yes 5 22 24 9 2.5 (0.8–7.3)
 No 17 74 201 79 P=0.09
 Unknown 1 4 28 11  
           
Axillary surgery          
 Five or less lymph nodes removed 4 17 40 16 1.2 (0.4–3.6)
 More than five lymph nodes removed 18 78 210 83 P=0.79
 Unknown 1 4 3 1  
           
Mean number of lymph nodes removed 11.4 Range 0–32 11.3 Range 0–31 P=0.16
           
Axillary lymph node metastases          
 Node-negative 11 48 130 51 0.9 (0.4–2.2)
 Node-positive 11 48 120 47 P=0.86
 Unknown 1 4 3 1  
           
Mean number of lymph nodes affected 2.7 Range 0–20 2.2 Range 0–24 P=0.10
           
Women with distant metastases at time of diagnosis 1 4 4 2 P=0.36
a

Women with implants (cases) compared with women from the background population (controls). Women with missing information with regard to the variable under study were excluded from the analysis.

b

Ductal carcinomas vs all other cancers.

c

Malignancy grade I vs malignancy grade II and III grouped together.

d

Mastectomy vs lumpectomy. In case of conversion from lumpectomy to mastectomy, the category was mastectomy. In cases of biopsy only, the category was lumpectomy.

e

Based on medical record information for 22 cases and 23 controls. For the remainder, the DBCG-data were used.