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. 1993 Jun;67(6):3601–3604. doi: 10.1128/jvi.67.6.3601-3604.1993

Legitimate and illegitimate cleavage of human immunodeficiency virus glycoproteins by furin.

Y Morikawa 1, E Barsov 1, I Jones 1
PMCID: PMC237708  PMID: 8497067

Abstract

Coexpression of human immunodeficiency virus type 1 glycoproteins with the subtilisin-like protease furin leads to processing of gp160 and gp140, a truncated form of gp160, to gp120. In addition, we show that gp120 itself is further cleaved by furin at sites near the primary cleavage site and within the V3 loop.

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Selected References

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