Table 4. Area under the DNA-adduct–time curve (AUA) in WBC and AUC of unbound platinum in plasma in 76 patients.

	Course	1	2	3	4	5	6
AUA (pg Pt h μg−1 DNA)	Mean	16.5	22.6	24.9	23.9	26.9	28.9
	s.d.	3.2	4.1	4.6	4.4	5.3	4.8
	Range	10.2–29.0	16.7–39.1	19.5–45.8	16.1–42.1	17.4–42.1	20.6–52.4
	N	76	75	65	49	49	31
AUC (μg h ml−1)	Mean	2.1	2.9	2.7	ND	ND	ND
	s.d.	0.5	0.6	0.4
	Range	1.1–3.5	2.2–4.1	2.1–4.4
	N	76	75	65

ND=not determined.