Table 3. Test performance of HC2 and cytology at different thresholds for detection of histologically confirmed CIN2+ or CIN3+.

	Sensitivity %		Specificity %		PPV %		NPV %
For CIN2+		95% CI		95% CI		95% CI		95% CI	Referred
PapIIw+	43.5%	30.0–58.0	98.0%	96.7–98.8	11.4%	7.5–16.9	99.7%	98.7–99.9	2.2%
PapIII+	37.0%	24.4–51.6	99.4%	98.5–99.8	27.0%	17.5–39.2	99.6%	98.8–99.9	0.8%
HPV	97.8%	86.3–99.7	95.3%	93.5–96.6	10.9%	8.2–14.2	100.0%	55.3–100	5.2%
HPV/PapIIw+	100.0%	93.7–100	93.8%	91.8–95.3	8.6%	6.5–11.3	100.0%	98.8–100	6.8%
For CIN3+
PapIIw+	46%	30.8–61.9	98.0%	96.7–98.8	9.7%	6.1–15	99.7%	98.8–99.9	2.2%
PapIII+	40.5%	26.1–56.8	99.4%	98.5–99.8	23.8%	14.9–35.8	99.7%	98.9–99.9	0.8%
HPV	97.3%	83.2–99.6	95.2%	93.4–96.5	8.7%	6.3–11.8	100.0%	55.3–100	5.2%
HPV/PapIII+	100.0%	93.7–100	94.9%	93.1–96.2	8.4%	6.2–11.4	100.0%	99.1–100	5.6%