Table 1. Mutations in coding region of the bak gene in cervical carcinoma.
Mutations at |
||||||
---|---|---|---|---|---|---|
Stage | No. of cases | Cases with mutation | exon 3 | exon 4 | exon 6 | |
Cancerous tissues | II | 12 | 1 | 1a | 0 | 0 |
III | 30 | 5 | 3b | 2c | 1d | |
Total | – | 42 | 6e | 4 | 2 | 1 |
Non-neoplastic tissues | – | 32 | 0 | 0 | 0 | 0 |
Codon 60 (ATG→GTG: Met→Val).
Codon 30 (GAC→AAC: Asp→Asn)+codon 57 (GAC→AAC: Asp→Asn), codon 59 (GAG→GAA: Glu→Glu).
Codon 74 (GTG→ATG: Val→Met), codon 80 (ATC→ACC: Leu→Thr).
Codon 191 (GTG→GCG: Val→Ala).
P<0.05 vs control by Fisher's exact test.