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. 2003 May 13;88(10):1587–1591. doi: 10.1038/sj.bjc.6600943

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Copyright © 2003 Cancer Research UK

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(A) CISH, only one or two signals are present in the nucleus of tumour cells (NAC). (B) Same case analysed with FISH (NAF). Pink dots correspond to HER2 probe and green dots correspond to centromere 17 probe. (C) CISH, six signals are present in the nucleus of tumour cells (LAC). (D) Same case analysed with FISH (LAF) with a ratio of HER2 dots/centromere 17 dots=3. (E) CISH, large gene copy clusters are present in the nucleus of tumour cells (HAC). (F) Same case analysed with FISH (HAF).